![]() Actas Esp Psiquiatr 39: 180–190.īhattacharyya S, Fusar-Poli P, Borgwardt S, Martin-Santos R, Nosarti C, et al. Drug Alcohol Depend 79: 11–22.įernandez-Artamendi S, Fernandez-Hermida JR, Secades-Villa R, Garcia-Portilla P (2011) Cannabis and mental health. Accessed 2 February 2012.Ĭhen CY, O'Brien MS, Anthony JC (2005) Who becomes cannabis dependent soon after onset of use? Epidemiological evidence from the United States: 2000–2001. United Nations Office on Drugs and Crime (2011) World drug report 2011. Further studies should consider the use of convergent methodology, prospective large samples involving adolescent to adulthood subjects, and data-sharing initiatives.Įuropean Monitoring Centre for Drugs and Drug Addiction (2011) The state of the drugs problem in Europe. However, the results pointed out methodological limitations of the work conducted to date and considerable heterogeneity in the findings.Ĭhronic cannabis use may alter brain structure and function in adult and adolescent population. Functional neuroimaging studies suggest different patterns of resting global and brain activity during the performance of several cognitive tasks both in adolescents and adults, which may indicate compensatory effects in response to chronic cannabis exposure. These effects may be related to the amount of cannabis exposure. Neuroimaging studies provide evidence of morphological brain alterations in both population groups, particularly in the medial temporal and frontal cortices, as well as the cerebellum. Eight studies were in adolescent population. One hundred and forty-two studies were identified, of which 43 met the established criteria. ![]() Only neuroimaging studies involving chronic cannabis users with a matched control group were considered. Papers published until August 2012 were included from EMBASE, Medline, PubMed and LILACS databases following a comprehensive search strategy and pre-determined set of criteria for article selection. We conducted a systematic review to assess the evidence of the impact of chronic cannabis use on brain structure and function in adults and adolescents. The growing concern about cannabis use, the most commonly used illicit drug worldwide, has led to a significant increase in the number of human studies using neuroimaging techniques to determine the effect of cannabis on brain structure and function.
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